Synthetic Organic, Medicinal & Material Chemistry Group
Dr. Seenuvasan Vedachalam, M.Sc.PhD
Assistant Professor,
Department of Chemistry,
National Institute of Technology Puducherry,
Kariakal-609 609
Union Territory Puducherry, India
Email: seenuvasanv@gmail.com;
PUBLICATIONS
- Bhagavat Gita-
“Do your duty unmindful of the results”
Journal Publications
20. Saravanan Saranya and Seenuvasan Vedachalam* Phosphazene-Based Covalent Organic Framework as an Efficient Catalyst (COF-1) for the Dehydration of Fructose to 5-HMF ACS Omega 2024, 9, 11, 12817–12824. (IF:4.1) (Corresponding author) Link
19. Seenuvasan Vedachalam,* Pandiaraj Sekar, Chandrasekhar Nithya, Nithya Murugesh, and Ramasamy Karvembu Dopant-Free Main group element supported Covalent Organic-Inorganic Hybrid Conducting polymer for sodium battery application. ACS Applied Energy Materials. 2022, 4, 9, 9341-9352. (IF:6.959) (Corresponding author) Link
18. Pandiaraj Sekar, Nithya Murugesh, Ramasamy Shanmugam, Shanmugam Senthil Kumar, Stefano Agnoli, Narendraraj Chandran, Seenuvasan Vedachalam, and Ramasamy Karvembu Phosphazene-based covalent organic polymer decorated with NiCo2O4 nanocuboids as a trifunctional electrocatalyst: A unique replacement for the conventional electrocatalysts” ACS Applied Energy Materials. 2021, 4, 9341.(IF:6.959). Link
17. Nithya Murugesh, R. Karvembu and Seenuvasan Vedachalam* A Convenient Synthesis of Iguratimod-Amine Precursor via NHC-Catalyzed Aldehyde-Nitrile Cross Coupling Reaction, Chemistry Select, 2020, 5, 13916. (IF: 2.1) Corresponding author Link
16. Nithya Murugesh, R. Karvembu and Seenuvasan Vedachalam* Base-induced regioselective radical arylation of 3-aminochromone with aryl hydrazine, Org. Biomol. Chem. 2020, 18, 7884. (IF-3.876) (Corresponding author) Link
15. Priya Mehta, Seenuvasan Vedachalam, Gopal Sathyaraj, Somenath Garai, Gangasalam Arthanareeswaran, Kamatchi Sankaranarayanan Fast Sensing Ammonia at Room Temperature: Using Proline Ionic Liquid Incorporated Cellulose Acetate Membranes, J. Mol. Liq. 2020, 305, 112820. (IF: 6.1) Link.
14. Nithya Murugesh, Jebiti Haribabu, Krishnamoorthy Arumugam, Chandrasekar Balachandran, Rajagopal Swaathy, Shin Aoki, Anandaram Sreekanth, Ramasamy Karvembu and Seenuvasan Vedachalam* NHC catalysed green synthesis of functionalized chromone: DFT mechanistic insights and in vitro activities in cancer cells, New J. Chem., 2019, 43, 13509-13525 (IF:3.6). (Corresponding author) Link
13. Seenuvasan Vedachalam,* Nithya Murugesh, Priyanka Chakraborty, Ramasamy Karvembu and Xue-Wei Liu, NHC catalyzed enantioselective Coates-Claisen rearrangement: A rapid access to the dihydropyran core for Oleuropein based Secoiridoids, New J. Chem., 2018, 42, 1832. (IF:3.6). (Corresponding author) Link
12. Sumava Santra, Sandhya Kortagere, Seenuvasan Vedachalam, Sanjib Gogoi, Tamara Antonio, Martin E.A. Reith, Aloke Dutta. Novel potent dopamine-norepinephrine and triple update inhibitors based on the (2S,4R,5R-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template and their molecular interaction with monoamine transporters. ACS Chem. Neurosci. 2021,12, 1406. (IF:4.41) Link
11. Banibrata Das, Seenuvasan Vedachalam, Dan Luo, Tamara Antonio, Maarten Reith, Aloke Dutta., Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson’s Disease, J. Med Chem. 2015, 58, 9179−9195 (IF:6.25). Link
10. Soumava Santra, Horrick Sharma, Seenuvasan Vedachalam, Tamara Antonio, Maarten Reith, Aloke Dutta, Development of potent dopamine-norepinephrine uptake inhibitors (DNRI) based on (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template, Bioorganic. Med Chem. 2015, 23, 821. (IF:3.64). Link
9. Biswajit Maji, Ji Li, Wang Siming, Seenuvasan Vedachalam, Rakesh Ganguly and Xue-Wei Liu, N-Heterocyclic Carbene Catalyzed Homoenolate-Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5-Carbon-Synthon δ-Nitroester, Angew. Chem., Int. Ed. 2012, 51, 8276-8280 (IF:15.336). Link
8. Seenuvasan Vedachalam, Shi Min Tan, Hui Ping Teo, and Xue-Wei Liu, N-Heterocyclic Carbene Catalyzed C–Glycosylation: A Concise Approach from Stetter Reaction, Org. Lett. 2012, 14, 174−177 (IF:6.05) Link
7. Biswajit Maji, Seenuvasan Vedachalam, Xin Ge, Shuting Cai, and Xue-Wei Liu, N-Heterocylic Carbene-Mediated Oxidative Etherification of Aldehydes: Ester formation and Mechanistic studies, J. Org. Chem. 2011, 76, 3016–3023 (IF:4.35). (Featured article) Link
6. Seenuvasan Vedachalam, Qian-Ling Wong, Biswajit Maji, Jing Zeng Jimei Ma and Xue-Wei Liu, N–Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones, Adv. Synth. Cata., 2011, 353, 219−225 (IF:6.0). (This paper has been highlighted in Synfacts for its important insights, Synfacts, 2011, 5, 0476) Link
5. Seenuvasan Vedachalam, Bo-Hwa Choi, Kalyan Kumar Pasunooti, Kun Mei Ching, Kijoon Lee, Ho Sup Yoon, Xue-Wei Liu, Glycosylated Porphyrin Derivatives and Their Photodynamic Activity in Cancer Cells, Med. Chem. Comm., 2011, 2, 371−377 (IF:2.5). (One of the most accessed top 10 papers in Medicinal Chemistry & Communications for the month of May-2011) Link
4. Jing Zeng, Seenuvasan Vedachalam, Shaohua Xiang, and Xue-Wei Liu, Direct C-Glycosylation of Organotrifluoroborates with Glycosyl Fluorides and Its Application to the Total Synthesis of (+)-Varitriol, Org. Lett. 2011, 13, 42−45.(IF:6.05). Link
3. Seenuvasan Vedachalam, Jing Zeng, Bala kishan Gorityala, Meraldo Antonio and Xue-wei Liu, N-Heterocyclic Carbene Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromone, Org. Lett. 2010, 12, 352−355 (IF:6.05). (This paper has been highlighted in Synfacts for its important insights, Synfacts, 2010, 3, 0352) Link
2. Kalyan Kumar Pasunooti, Min Li Leow, Seenuvasan Vedachalam, Bala Kishan Gorityala, Xue-Wei Liu, A general and mild copper-catalyzed three-component synthesis of protected homoallyl amines, Tetrahedron Lett., 2009, 50, 2979−2981(IF:2.5). Link
1. Kalyan KumarPasunooti, RenliangYangb, Seenuvasan Vedachalam, Bala KishanGorityala, Chuan-Fa Liu, Xue-WeiLiu, Synthesis of 4-mercapto-l-lysine derivatives: Potential building blocks for sequential native chemical ligation Bioorg. Med. Chem. Lett., 2009, 19, 6268−6271 (IF:2.82) Link
Book Chapter
1. Saravanan Saranya, Seenuvasan Vedachalam* Wiley-VCH GmbH Publisher, Weinheim, Germany ISBN 9783527350704 Title Schiff Base Metal Complexes: Synthesis and Applications, Chapter 15: Application as Catalyst, 2023
Conference Publications
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Indo-US Chemical Safety and Security workshop, Seenuvasan Vedachalam Organizers: USA Safety and Security organization, Oak Ridge National Lab, USA and National Safety Council, India. 6-9 August 2018, SRM-Institute of Science and Technology, Chennai, Tamilnadu.
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Development of a Highly Potent Analogues for Parkinson Disease, Seenuvasan Vedachalam “International Conference on Synthetic Material for Science and Engineering application (SMSEA-2018)”, 11 th April 2018, Karur, Tamilnadu (Invited Lecture)
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Glycosylated porphyrin derivatives and their Photodynamic activity in cancer cells. Seenuvasan Vedachalam "International Workshop on Recent Material for Health care & Industrial Application (IWRM-2018)" 22-23 Jan 2018, Anna University, Chennai, Tamilnadu (Poster Presentation)
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An efficient NHC catalysed green synthesis of chromones "International Conference on Emerging Frontiers in Chemical Science " Nithya Murugesh, Seenuvasan Vedachalam, Ramasay Karvembu 23-25 Sep 2017, Farook College, Kozhikode, Kerala, India (Poster Presentation)
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An efficient NHC catalysed green synthesis of chromones National level conference on “Innovative research on material science – IRMS 2017” Seenuvasan Vedachalam, Oct 2017 Sri Akilandeswari Womens college, Wandiwash, Tamilnadu
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N-Heterocyclic Carbene Catalyzed C–Glycosylation: A Concise Approach for the formal synthesis of Scleropentasides A Seenuvasan Vedachalm, National level conference on “Innovative research on material science – IRMS 2017” Nithya Murugesh, Seenuvasan Vedachalam, Oct 2017 Sri Akilandeswari Womens college, Wandiwash, Tamilnadu
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N-Heterocyclic Carbene Catalyzed –Glycosylation: A Concise Approach for the formal synthesis of Scleropentasides A, Seenuvasan Vedachalam and Xue-Wei Liu “21st International Conference on Organic Synthesis", December 11-16, 2016, IIT-Bombay, Mumbai, India (Poster Presentation)
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Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure−Activity Relationship Study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson’s Disease" Seenuvasan Vedachalam, Banibrata Das, Dan Luo, Tamara Antonio, Maarten E. A. Reith and Aloke K. Dutta. "World Congress on Drug Discovery" Nov-23-25, 2016, IISc-Bangalore, Bangalore, India (Oral Presentation)
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"Further Structure Activity Relationship (SAR) study of novel hybrid N6-(2-(4-(1H-Indole)piperazine-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: Development ofhighly potent and selective D3 receptor preferring agonist molecules." Seenuvasan Vedachalam, Banibrata Das, Tamara Antonio, Maarten. E. A. Reith, Aloke Dutta “” Wayne State University, Pharmaceutical Research and Development. (Poster Presentation) ""
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"Further Structure Activity Relationship (SAR) study of novel hybrid N6-(2-(4-(1H-Indole)piperazine-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: Development ofhighly potent and selective D3 receptor preferring agonist molecules." Seenuvasan Vedachalam, Banibrata Das, Tamara Antonio, Maarten. E. A. Reith, Aloke Dutta “” SanFrancisco, California, North America. (Poster Presentation)
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“N-Heterocyclic Carbene Catalyzed Chromone Synthesis.” Seenuvasan Vedachalam and Xue-Wei Liu “” Anaheim, California, North America. (Poster Presentation)
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“N-Heterocyclic Carbene Catalyzed Intramolecular Aldehyde Nitrile Cross Coupling: An Easy Access to 3-Aminochromones.” Seenuvasan Vedachalam and Xue-Wei Liu “7th WOCJC National Tsing Hua University” Taiwan Sep 4−6, 2010 (Poster, Won best poster award)
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“N-Heterocyclic Carbene Catalyzed Intramolecular Aldehyde Nitrile Cross Coupling: An Easy Access to 3-Aminochromones.” Seenuvasan Vedachalam and Xue-Wei Liu “6th Asian-European Symposium on Metal Mediated Efficient Reactions” June 7−9 2010, NTU, Singapore. (Poster) and “Kyushu-NTU (CBC) Joint Symposium 2010” Jan 28, 2010, NTU, Singapore. (Both Oral & Poster Presentation)